Natural infection and vaccination may provide long-lasting immunity, noted Prof Tambyah. Related Story Expert explains why combination of Covid-19 jabs and mild infection can be so powerfulĪ previous Duke-NUS study done with NCID on survivors of the severe acute respiratory syndrome, or Sars, showed that they had a powerful antibody boost against a range of beta-coronaviruses when they were given a single dose of Covid-19 vaccine.
In the best-case scenario, with a high vaccination rate and as more of the population is infected with Covid-19, the risk of severe disease will be low, said Prof Tambyah.
The immune response is actually a lot more than just antibody levels," he added.Īside from the T-cell response, the immune response also comprises the innate immune response, which is the body's first line of defence against all antigens.Īntibodies can protect against most infections, such as hepatitis B and measles.īut "not so good" antibodies, which may be produced following vaccinations against the respiratory syncytial virus and possibly dengue, could lead to severe infections, he noted.Īs for Covid-19, it is unclear whether those who had breakthrough infections would be protected against reinfection, given that current vaccines do not protect against infection very well, said Prof Tambyah. "In fact, many individuals who were doubly vaccinated had high titres of antibodies yet developed symptomatic Covid-19 infection. Professor Paul Tambyah, president of the Asia Pacific Society of Clinical Microbiology and Infection, said having high antibody levels may not always correlate with greater protection against infection. Related Story Experts advise young adults with underlying conditions to get Covid-19 jabs
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